Description

6,6-Difluorospiro[3.3]heptan-2-one is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily sought after by R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in CNS and oncology research.
• Medicinal Chemistry Scaffold: Used to introduce the metabolically stable spiro[3.3]heptane core and fluorine atoms into drug candidates to optimize pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the development of new generation herbicides and pesticides with improved efficacy.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating specialized ligands and catalysts.
• Advanced Material Synthesis: A precursor for fluorinated polymers or specialty chemicals with unique physical properties.
• Academic & Industrial R&D: Used in exploratory synthetic chemistry for method development and library synthesis.

Basic Information

Product Name	6,6-Difluorospiro[3.3]heptan-2-One
CAS No.	2137641-05-3
Molecular Formula	C7H8F2O
Molecular Weight	146.14 g/mol
Synonyms	6,6-Difluorospiro[3.3]heptan-2-one; 2,2-Difluorospiro[3.3]heptan-6-one; Spiro[3.3]heptane-2,6-dione, 2,2-difluoro-; 2137641-05-3; Difluorospiroheptanone
EINECS	Contact for details

Quality Control

Our 6,6-Difluorospiro[3.3]heptan-2-one is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.