Description

Cyclobutanecarboxylic Acid, 3-(Methylamino)-, 1-Methylethyl Ester, cis- is a specialized chiral intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, offering a unique cyclobutane scaffold with a defined stereocenter. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its specific stereochemistry is crucial for achieving desired efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, constrained ring systems.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the cyclobutane structure can impart unique biological activity and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or building block for specialty polymers with tailored thermal and mechanical properties derived from the strained cyclobutane ring.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its defined three-dimensional structure.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-(Methylamino)-, 1-Methylethyl Ester, cis-
CAS No.	2136718-64-2
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	cis-3-(Methylamino)cyclobutanecarboxylic acid isopropyl ester; Isopropyl cis-3-(methylamino)cyclobutanecarboxylate; cis-1-Methylethyl 3-(methylamino)cyclobutanecarboxylate; (1R,3S)- or (1S,3R)-3-(Methylamino)cyclobutanecarboxylic acid 1-methylethyl ester; cis-3-Methylaminocyclobutanecarboxylic acid isopropyl ester
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-(Methylamino)-, 1-Methylethyl Ester, cis- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.