Description

Methyl 3-(Benzyloxy)-1-((tert-Butoxycarbonyl)Amino)-4-Oxo-1,4-Dihydropyridine-2-Carboxylate CAS NO 2136287-59-5 is a high-purity, advanced pharmaceutical intermediate featuring a protected amino and carboxylate functional group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under GMP conditions.
• Protease & Kinase Inhibitor Synthesis: Core scaffold in the development of enzyme inhibitors targeting specific disease pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for clinical trials.
• Academic Research: Used in university and institutional labs for exploring new synthetic methodologies and biological targets.

Basic Information

Product Name	Methyl 3-(Benzyloxy)-1-((tert-Butoxycarbonyl)Amino)-4-Oxo-1,4-Dihydropyridine-2-Carboxylate
CAS No.	2136287-59-5
Molecular Formula	C19H22N2O6
Molecular Weight	374.39 g/mol
Synonyms	1-((tert-Butoxycarbonyl)Amino)-3-(Benzyloxy)-4-Oxo-1,4-Dihydropyridine-2-Carboxylic Acid Methyl Ester; Methyl 1-Boc-amino-3-benzyloxy-4-oxo-1,4-dihydropyridine-2-carboxylate; 1-N-Boc-3-O-benzyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl ester; Boc-Protected Pyridone Derivative; 2-Pyridone-2-carboxylate Intermediate; CAS 2136287-59-5
EINECS	Contact for details

Quality Control

Our Methyl 3-(Benzyloxy)-1-((tert-Butoxycarbonyl)Amino)-4-Oxo-1,4-Dihydropyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development from research to commercial scale with specifications that meet the stringent requirements of cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.