Description

Pomalidomide-Peg1-Azide is a high-purity, bifunctional chemical linker designed for advanced pharmaceutical research and development. This compound is critical for creating antibody-drug conjugates (ADCs) and targeted therapeutics by enabling precise, site-specific bioconjugation. It is primarily utilized by research scientists and process development teams in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via click chemistry.
• Targeted Drug Delivery Systems: Enables the construction of precision therapeutics for oncology and other disease areas.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Used as a component in the design of heterobifunctional molecules for targeted protein degradation.
• Bioconjugation and Labeling: Facilitates the attachment of fluorescent dyes, peptides, or other molecules to proteins and biomolecules for diagnostic and research applications.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and cellular pathways through bioorthogonal chemistry.
• Pre-Clinical and Process Development: Supports scale-up and optimization of conjugation processes for novel therapeutic candidates.

Basic Information

Product Name	Pomalidomide-Peg1-Azide
CAS No.	2133360-04-8
Molecular Formula	C20H22N6O6
Molecular Weight	442.43 g/mol
Synonyms	Pomalidomide-PEG1-N3; 4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)butyl 5-azidopentanoate; Pomalidomide-PEG1-azide; Pomalidomide-azide-PEG1; Azide-PEG1-Pomalidomide; Pomalidomide PEG Azide; Pomalidomide Azido-PEG Conjugate
EINECS	Contact for details

Quality Control

Our Pomalidomide-Peg1-Azide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and ensure long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.