Description

4,7-Diazaspiro[2.5]Octane-4-Carboxylic Acid, 7-(2-Hydroxy-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-7-Yl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic architecture. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or oncology.
• Medicinal Chemistry Research: Used as a versatile scaffold in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for Good Manufacturing Practice (GMP) production.
• Bioconjugation & Probe Development: Its functional groups make it suitable for developing chemical probes, diagnostic agents, or targeted drug conjugates in biochemical research.
• Academic & Institutional R&D: Utilized in university and institutional laboratories for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4,7-Diazaspiro[2.5]Octane-4-Carboxylic Acid, 7-(2-Hydroxy-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-7-Yl)-, 1,1-Dimethylethyl Ester
CAS No.	2133298-72-1
Molecular Formula	C20H24N4O5
Molecular Weight	400.43 g/mol
Synonyms	tert-Butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate; 4,7-Diazaspiro[2.5]octane-4-carboxylic acid, 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-, 1,1-dimethylethyl ester; 7-(2-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl ester; BOC-protected diazaspiro pyridopyrimidinone intermediate; CAS 2133298-72-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects with quality standards suitable for cGMP compliance upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.