Description

3-Carboxy-4-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative used as a key building block in advanced organic synthesis. This compound matters for its role as a protected boronic acid, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex multi-step reactions. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures for active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those containing biaryl or heterobiaryl motifs via palladium-catalyzed cross-coupling.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable organoboron partner for coupling with various aryl/vinyl halides or triflates to form carbon-carbon bonds.
• Ligand and Catalyst Development: Used in the research and development of new ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Agrochemical Synthesis: Acts as a building block for creating advanced active ingredients with specific biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes.

Basic Information

Product Name	3-Carboxy-4-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-71-6
Molecular Formula	C15H21BO5
Molecular Weight	292.14 g/mol
Synonyms	(3-Carboxy-4-methoxyphenyl)boronic acid pinacol ester; 2-(4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid (tautomer); 4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; Boronic acid, B-[3-(carboxy)-4-methoxyphenyl]-, 1,1-dimethylethyl ester; Pinacol (3-Carboxy-4-methoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 3-Carboxy-4-Methoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.