Description

2-Bromo-3-Methoxypyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and advanced materials researchers for developing novel active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based drug candidates in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for creating functionalized ligands in catalysis and organic electronic materials.
• Chemical Biology: Employed in the synthesis of molecular probes and bio-conjugates for target identification and validation.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura couplings to introduce the 2-bromo-3-methoxypyridine moiety into complex molecules.
• Library Synthesis: Enables high-throughput parallel synthesis for medicinal chemistry and hit-to-lead optimization programs.

Basic Information

Product Name	2-Bromo-3-Methoxypyridine-5-Boronic Acid Pinacol Ester
CAS No.	2121512-66-9
Molecular Formula	C₁₂H₁₇BBrNO₃
Molecular Weight	314.0 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-bromo-3-methoxypyridine; (2-Bromo-3-methoxypyridin-5-yl)boronic acid pinacol ester; 2-Bromo-3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Bromo-3-methoxypyridine-5-boronic acid pinacol ester; 2-Bromo-3-methoxy-5-pyridineboronic acid pinacol ester; 2121512-66-9; 2-Bromo-3-methoxypyridin-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Methoxypyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.