Description

n-(Azido-Peg4)-n-Boc-Peg4-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a tert-butyl ester-protected carboxylic acid, separated by extended PEG spacers. This compound is engineered to facilitate high-efficiency, site-specific bioconjugation via click chemistry, enabling the construction of complex molecular architectures. It is a critical reagent for researchers and developers in pharmaceutical R&D, bioconjugation, and advanced materials science, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific coupling of payloads (e.g., toxins, dyes, drugs) to antibodies, proteins, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Peptide and Protein Modification: Introduction of PEG chains to improve solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Polymer and Materials Science: Building block for synthesizing functionalized hydrogels, smart materials, and surface coatings with tailored properties.
• Diagnostic Probe Synthesis: Construction of imaging agents and diagnostic probes by conjugating reporter molecules to targeting ligands.
• Drug Delivery Systems: Key component in the design of prodrugs and nanocarrier systems for controlled release and targeted delivery.
• Chemical Biology Tool: Used in activity-based protein profiling (ABPP) and other research applications to study biomolecular interactions.

Basic Information

Product Name	n-(Azido-Peg4)-n-Boc-Peg4-T-Butyl Ester
CAS No.	2112737-20-7
Molecular Formula	C33H64N4O14
Molecular Weight	740.88 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid, 15-[(1,1-dimethylethoxy)carbonyl]-3,6,9,12-tetraoxapentadec-1-yl ester; Azido-PEG4-Boc-PEG4-t-butyl ester; Boc-PEG4-Azide (t-butyl ester form); N-(Azido-PEG4)-N-Boc-PEG4-COOtBu; Heterobifunctional PEG linker, Azide/Boc-PEG4-t-Butyl Ester; 15-{[(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethoxy)carbonyl]amino}-4,7,10,13-tetraoxa-16-azaheptadecanoic acid tert-butyl ester; t-Butyl 15-azido-4,7,10,13-tetraoxa-16-azaheptadecanoate, Boc-protected
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg4)-n-Boc-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.