Description

n-(Azido-Peg3)-n-Boc-Peg3-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal azide group and a tert-butyl ester protected carboxylic acid, separated by Boc-protected and triethylene glycol spacer units. This compound is specifically engineered for applications in bioconjugation and materials science, where its orthogonal reactive handles enable controlled, multi-step assembly of complex architectures. It is a critical building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis, facilitating the creation of targeted drug delivery systems, diagnostic agents, and functional biomaterials.

Application

• Bioconjugation and Linker Chemistry: Used as a versatile heterobifunctional crosslinker for attaching molecules (e.g., drugs, dyes, peptides) to proteins, antibodies, or nanoparticles via click chemistry (azide-alkyne cycloaddition) and subsequent deprotection/activation.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key intermediate in the synthesis of PEGylated linkers for constructing stable, cleavable, or non-cleavable ADCs, improving pharmacokinetics and payload delivery.
• Polymer and Biomaterial Functionalization: Enables the introduction of reactive azide groups and protected carboxylates into polymer backbones or hydrogel matrices for post-synthetic modification and surface engineering.
• Peptide and Protein Modification: Facilitates site-specific PEGylation (PEG3) of peptides and proteins to enhance solubility, stability, and circulation half-life while minimizing immunogenicity.
• Diagnostic Probe Synthesis: Employed in the construction of imaging probes and contrast agents for modalities like fluorescence imaging or MRI, where controlled attachment of signaling molecules is required.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected, PEG-containing building block for introducing functional handles and improving the physicochemical properties of synthetic peptides.
• Click Chemistry Toolkits: A fundamental reagent in research kits and platforms dedicated to copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) reactions.
• Surface Immobilization and Microarray Fabrication: Used to create functionalized surfaces for biosensors, protein chips, and cell culture substrates by providing a reactive interface for subsequent biomolecule attachment.

Basic Information

Item	Details
Product Name	n-(Azido-Peg3)-n-Boc-Peg3-T-Butyl Ester
CAS No.	2112732-03-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Azido-3,6,9,12,15,18,21-heptaoxatricosan-23-oic acid, 23-[(1,1-dimethylethoxy)carbonyl]-1-azido-3,6,9,12,15,18,21-heptaoxatricosan-23-oate; 2,5,8,11,14,17,20-Heptaoxadocosan-22-oic acid, 1-azido-22-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester; Azido-PEG3-Boc-PEG3-t-butyl ester; N3-PEG3-Boc-PEG3-OtBu; Boc-PEG3-Azide-PEG3-t-butyl ester; tert-Butyl 1-azido-3,6,9,12,15,18,21-heptaoxatricosan-23-oate-23-carboxylate; Heterobifunctional PEG Azide t-Butyl Ester Boc Protected
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-Boc-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to relevant cGMP and ISO 9001 guidelines for the production of fine chemicals and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.