Description

n-(Azido-Peg3)-n-Boc-Peg4-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a protected carboxylic acid. This compound is engineered to enable precise, bioorthogonal conjugation strategies, primarily through copper-free click chemistry. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science, facilitating the creation of targeted drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific coupling of antibodies, proteins, or peptides with cytotoxic drugs, fluorophores, or other payloads.
• Click Chemistry Reagent: Utilized in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for labeling biomolecules without cytotoxic copper catalysts.
• PEGylation Linker: Serves as a spacer to improve the pharmacokinetic properties (solubility, stability, circulation time) of therapeutic biologics.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray slides to create bioactive interfaces.
• Polymer and Dendrimer Synthesis: A key monomer for constructing complex, branched polymeric architectures with defined functionality.
• Prodrug Synthesis: Designing cleavable linkers for controlled-release drug delivery mechanisms.
• Diagnostic Reagent Formulation: Development of contrast agents and imaging probes for in vitro and in vivo diagnostics.

Basic Information

Product Name	n-(Azido-Peg3)-n-Boc-Peg4-Acid
CAS No.	2112731-95-8
Molecular Formula	C28H53N5O13
Molecular Weight	667.75 g/mol
Synonyms	1-Azido-3,6,9,12,15,18,21-heptaoxatetratriacontan-34-oic acid, 34-tert-butyl ester; 2,5,8,11,14,17,20-Heptaoxadocosan-22-azido-1-oic acid, 1-(1,1-dimethylethyl) ester; Azido-PEG3-Boc-PEG4-acid; Boc-PEG4-Acid-PEG3-Azide; N-(Azido-PEG3)-N-Boc-PEG4-acid; Azido-PEG3-Boc-PEG4-COOH; Heterobifunctional PEG linker, Azide/Boc-PEG4-acid; 15-Azido-4,7,10,13-tetraoxa-1-hexadecanoic acid, 1-(1,1-dimethylethyl) ester, extended with PEG
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-Boc-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.