Description

n-(Azido-Peg3)-n-Boc-Peg3-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a protected carboxylic acid, designed for advanced bioconjugation and click chemistry applications. This compound is critical for creating stable, site-specific linkages in the development of complex biomolecules, drug delivery systems, and advanced materials. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for antibody-drug conjugate (ADC) development, peptide synthesis, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key building block for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Peptide and Protein Modification: Enables site-specific PEGylation to improve the pharmacokinetic properties, solubility, and stability of therapeutic peptides and proteins.
• Click Chemistry Reagent: The azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkynes for efficient and bioorthogonal labeling.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and microarray surfaces with specific functional groups for subsequent biomolecule attachment.
• Polymer and Dendrimer Synthesis: Acts as a versatile monomer or crosslinker in the synthesis of functionalized polymers and dendrimers for drug delivery applications.
• Diagnostic Probe Development: Facilitates the conjugation of fluorophores, radiolabels, or other reporter molecules to targeting ligands for imaging and diagnostic assays.

Basic Information

Product Name	n-(Azido-Peg3)-n-Boc-Peg3-Acid
CAS No.	2112731-52-7
Molecular Formula	C23H44N4O10
Molecular Weight	536.62 g/mol
Synonyms	1-Azido-3,6,9,12,15,18,21-heptaoxatetratriacontan-34-oic acid, 34-[(1,1-dimethylethoxy)carbonyl]amino]-; 15-Azido-4,7,10,13-tetraoxa-16-azaheptadecanoic acid, 1-(1,1-dimethylethyl) ester; Azido-PEG3-Boc-PEG3-acid; Boc-N-amido-PEG3-azide; N-(Azido-PEG3)-N-Boc-PEG3-acid; Heterobifunctional PEG linker, Azide-Boc-PEG3-acid; Azido-PEG3-t-butyl ester-PEG3-acid; 2112731-52-7
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-Boc-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.