Description

Methyltetrazine-Amido-Peg7-Azide is a heterobifunctional crosslinking reagent engineered for advanced bioconjugation and click chemistry applications. This compound matters for its unique combination of a bioorthogonal methyltetrazine group and a polyethylene glycol (PEG7) spacer terminated with an azide, enabling controlled, high-efficiency labeling of biomolecules. Researchers and developers in the fields of biopharmaceuticals, diagnostic probe development, and materials science require this reagent to create stable, site-specific conjugates for targeted drug delivery, imaging, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: For constructing stable, cleavable linkers between cytotoxic payloads and targeting antibodies.
• Fluorescent Probe & Diagnostic Agent Synthesis: Enables the site-specific attachment of dyes and reporter molecules to proteins, peptides, or oligonucleotides.
• Polymer & Biomaterial Surface Modification: Functionalizes surfaces with bioorthogonal handles for subsequent click chemistry reactions to immobilize biomolecules.
• Protein & Peptide Labeling: Facilitates the introduction of tags, PEG chains, or other functional groups onto specific sites within biological macromolecules.
• Live Cell Imaging: Used in pretargeting strategies where the tetrazine group reacts rapidly with trans-cyclooctene (TCO)-modified biomolecules for real-time visualization.
• Nanoparticle Functionalization: Conjugates targeting ligands or therapeutic agents to the surface of liposomes, dendrimers, or other nanocarriers.

Basic Information

Product Name	Methyltetrazine-Amido-Peg7-Azide
CAS No.	2112731-46-9
Molecular Formula	C31H51N11O9
Molecular Weight	721.81 g/mol
Synonyms	m-Tetrazine-PEG7-Azide; Methyltetrazine-PEG7-N3; 3-Methyl-1,2,4,5-tetrazine-PEG7-azide; Azido-PEG7-methyltetrazine; TZ-PEG7-N3; MeTz-PEG7-N3; 1-Azido-3,6,9,12,15,18,21-heptaoxatricosan-23-yl 6-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetate
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Amido-Peg7-Azide is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and moisture absorption. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize condensation.

Specification

Item	Specification
Appearance	Orange to red viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.