Description

Azido-Peg3-Succinimidyl Carbonate is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive NHS ester and a terminal azide group. This compound is essential for creating stable, well-defined bioconjugates through efficient click chemistry and amine coupling reactions. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science for modifying peptides, proteins, surfaces, and nanoparticles.

Application

• Bioconjugation and Protein Modification: Used to attach azide-functionalized molecules (e.g., drugs, labels, polymers) to amine-containing proteins, antibodies, or peptides via a stable amide bond.
• ADC (Antibody-Drug Conjugate) Linker Synthesis: Serves as a key building block for constructing cleavable or non-cleavable linkers in ADC development, leveraging the orthogonal reactivity of its functional groups.
• Surface Functionalization: Enables the introduction of azide groups onto amine-coated surfaces (e.g., chips, beads, nanoparticles) for subsequent click chemistry-based immobilization of biomolecules.
• PEGylation Reagent: Acts as a heterobifunctional PEG spacer to introduce hydrophilic PEG chains and an azide handle onto therapeutic molecules, improving solubility and pharmacokinetics.
• Hydrogel and Biomaterial Fabrication: Employed in crosslinking polymer networks for creating tunable hydrogels and scaffolds used in tissue engineering and drug delivery systems.
• Diagnostic Probe Development: Facilitates the synthesis of fluorescent, radioactive, or other diagnostic probes by conjugating reporting agents to targeting ligands.

Basic Information

Product Name	Azido-Peg3-Succinimidyl Carbonate
CAS No.	2110448-98-9
Molecular Formula	C16H26N4O9
Molecular Weight	418.40 g/mol
Synonyms	NHS-PEG3-Azide; Azido-PEG3-NHS ester; 3-Azidopropyl-PEG3-NHS carbonate; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propyl carbonate; N-(3-Azidopropyl)-3,6,9,12-tetraoxapentadecan-15-oic acid succinimidyl ester; Azido-PEG3-SC; PEG3-Azide-NHS ester; Azido-triethyleneglycol-NHS carbonate
EINECS	Contact for details

Quality Control

Our Azido-Peg3-Succinimidyl Carbonate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, and other polar aprotic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.