Description

n-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-N'-(1-Tetrahydro-2H-Pyran-4-Yl-1H-Pyrazol-4-Yl)Urea is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is valued for its complex heterocyclic structure, which is critical for modulating biological activity in novel therapeutic agents. It is primarily sought by pharmaceutical companies and research institutions engaged in the discovery of new small-molecule drugs, particularly in oncology and inflammatory disease pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Kinase Inhibitor Research: Core scaffold for the development of targeted kinase inhibitors due to its pyridine and pyrazole motifs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Chemical Biology: Serves as a probe or tool compound for investigating specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	n-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-N'-(1-Tetrahydro-2H-Pyran-4-Yl-1H-Pyrazol-4-Yl)Urea
CAS No.	2108968-71-2
Molecular Formula	C17H18F3N5O2
Molecular Weight	381.35 g/mol
Synonyms	1-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)urea; N-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)-N'-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)urea; Urea, N-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-N'-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-; CAS 2108968-71-2
EINECS	Contact for details

Quality Control

Our n-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-N'-(1-Tetrahydro-2H-Pyran-4-Yl-1H-Pyrazol-4-Yl)Urea is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and traceable to each production lot, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.