Description

(2-Bromo-4,5-Dimethoxyphenoxy)Trimethylsilane is a high-purity organosilicon reagent featuring a brominated, dimethoxylated aromatic ring. This compound matters as a versatile and protected synthetic intermediate, enabling precise chemical transformations in complex molecule construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced organic synthesis, including the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those requiring functionalized aromatic ethers.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the bromo and silyl ether groups offer strategic sites for further modification.
• Material Science Research: Serves as a precursor for functionalized monomers or surface-modifying agents in the development of specialty polymers and advanced materials.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing novel ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a synthetic handle for creating molecular probes and tags used in biochemical and cellular research.

Basic Information

Product Name	(2-Bromo-4,5-Dimethoxyphenoxy)Trimethylsilane
CAS No.	2104695-66-9
Molecular Formula	C₁₁H₁₇BrO₃Si
Molecular Weight	305.24 g/mol
Synonyms	1-Bromo-2-((trimethylsilyl)oxy)-4,5-dimethoxybenzene; 2-Bromo-4,5-dimethoxyphenyl trimethylsilyl ether; Trimethyl(2-bromo-4,5-dimethoxyphenoxy)silane; 4,5-Dimethoxy-2-bromophenoxytrimethylsilane; (2-Bromo-4,5-dimethoxyphenoxy)(trimethyl)silane; TMS ether of 2-bromo-4,5-dimethoxyphenol
EINECS	Contact for details

Quality Control

Our (2-Bromo-4,5-Dimethoxyphenoxy)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports cGMP-compliant workflows for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.