Description

Mal-Amido-Peg12-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and an N-hydroxysuccinimide (NHS) ester. This compound is engineered for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined constructs. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise and reliable linking chemistry is paramount.

Application

• Antibody-Drug Conjugate (ADC) Development: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• PEGylation of Peptides and Proteins: To modify therapeutic biomolecules, improving their solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: For immobilizing proteins, antibodies, or other ligands onto biosensor chips, nanoparticles, or diagnostic assay substrates.
• Crosslinking for Hydrogel Formation: Used in the synthesis of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Diagnostic Reagent Conjugation: In the production of enzyme-linked or fluorescently labeled probes and detection antibodies for immunoassays.
• Biomaterial Modification: To introduce functional groups onto polymer backbones or medical device surfaces for enhanced biocompatibility.

Basic Information

Product Name	Mal-Amido-Peg12-Nhs Ester
CAS No.	2101722-60-3
Molecular Formula	C58H98N4O28
Molecular Weight	~1347.4 g/mol
Synonyms	Maleimide-PEG12-NHS Ester; MAL-PEG12-NHS; NHS-PEG12-Maleimide; N-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)-2,5-dioxopyrrolidine-1-carboxamide; 1-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl]pyrrole-2,5-dione NHS ester
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg12-Nhs Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and functional group analysis, to ensure consistency and performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Purity (Maleimide)	≥ 90%
Functional Group Purity (NHS Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.