Description

5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86-Octacosaoxa-2-Azanonaoctacontanedioic Acid, 1-(9H-Fluoren-9-Ylmethyl) Ester is a high-purity, specialized PEGylated Fmoc-protected amino acid derivative designed for advanced bioconjugation and peptide synthesis. Its core value lies in providing a water-soluble, spacer-linked building block that facilitates the controlled attachment of bioactive molecules. This compound is essential for researchers and manufacturers in pharmaceutical development, biotech, and advanced material science who require precise molecular engineering.

Application

• Peptide & Protein Modification: Used as a key intermediate for introducing hydrophilic polyethylene glycol (PEG) spacers to enhance solubility, stability, and pharmacokinetic properties of therapeutic peptides.
• Bioconjugation & Linker Chemistry: Serves as a heterobifunctional linker for coupling drugs, dyes, or targeting ligands to antibodies, proteins, or nanoparticles, leveraging its Fmoc-protected amine and carboxylic acid termini.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a specialized Fmoc-amino acid derivative for the automated synthesis of PEGylated peptide sequences, enabling the precise incorporation of long, flexible spacer arms.
• Drug Delivery System Development: A critical component in creating advanced drug delivery platforms, such as PEGylated prodrugs and polymer-drug conjugates, to improve bioavailability and reduce immunogenicity.
• Diagnostic Reagent Formulation: Utilized in the synthesis of contrast agents or fluorescent probes where controlled water solubility and linkage chemistry are paramount.
• Biomaterial & Hydrogel Fabrication: Acts as a functional monomer or cross-linker for creating biocompatible and tunable hydrogels for tissue engineering and controlled release applications.

Basic Information

Item	Details
Product Name	5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86-Octacosaoxa-2-Azanonaoctacontanedioic Acid, 1-(9H-Fluoren-9-Ylmethyl) Ester
CAS No.	2101605-02-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-NH-PEG27-COOH; Fmoc-Amino-PEG27-acid; N-α-Fmoc-27-amino-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82-octacosaoxa-3-azanonatriacontanedioic Acid; 1-Fluoren-9-ylmethyl 27-(9H-fluoren-9-ylmethoxycarbonylamino)-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82-octacosaoxa-3-azanonatriacontanedioate; Fmoc-27-amino-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82-octacosaoxa-3-azanonatriacontanedioic Acid; Heterobifunctional PEG Linker, Fmoc-NH-PEG27-COOH; PEG Spacer, Fmoc-protected
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical intermediate adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing critical specifications. Our quality management system supports compliance with cGMP guidelines for pharmaceutical applications, ensuring reliability for your most sensitive research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store the product under dry, inert conditions (e.g., under nitrogen or argon) at a controlled temperature of -20°C or below for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Store away from incompatible materials in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.