Description

2,5-Dioxopyrrolidin-1-Yl 3-(2-(4-Formylbenzamido)Ethoxy)Propanoate is a specialized bifunctional chemical linker featuring an activated NHS ester and a benzaldehyde group. This compound is engineered for efficient and selective conjugation chemistry, enabling the stable attachment of biomolecules under mild conditions. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of advanced diagnostic and therapeutic agents.

Application

• Bioconjugation Reagent: For the covalent coupling of peptides, proteins, and antibodies to surfaces, polymers, or other biomolecules via amine and aldehyde-specific chemistries.
• Proteomics Research: Used in cross-linking studies and mass spectrometry to investigate protein-protein interactions and structural analysis.
• Diagnostic Kit Development: A key intermediate in the synthesis of enzyme-linked immunosorbent assay (ELISA) components and other immunoassay reagents.
• Drug Delivery Systems: Facilitates the site-specific attachment of targeting ligands or drugs to carrier nanoparticles or polymers.
• Surface Functionalization: Enables the modification of biosensor chips, microarrays, and other solid supports with bioactive molecules.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a versatile linker in the research and development stages of ADC payload attachment.
• Material Science: Used to create functionalized hydrogels and biomaterials with tailored biological activity.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl 3-(2-(4-Formylbenzamido)Ethoxy)Propanoate
CAS No.	2101206-80-6
Molecular Formula	C₁₇H₁₈N₂O₇
Molecular Weight	362.34 g/mol
Synonyms	NHS-PEG2-CHO; 4-Formylbenzamide-PEG2-NHS ester; 3-(2-(4-Formylbenzamido)ethoxy)propanoic acid N-hydroxysuccinimide ester; N-Succinimidyl 3-(2-(4-formylbenzamido)ethoxy)propanoate; Benzaldehyde-PEG2-NHS; Aldehyde-PEG2-NHS ester; 4-Formylbenzoic acid PEG2 NHS ester; NHS-PEG2-4-formylbenzamide
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl 3-(2-(4-Formylbenzamido)Ethoxy)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for sensitive life science applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.