Description

Methoxycarbonyl-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative designed for advanced bioconjugation and pharmaceutical research. This compound serves as a critical building block for creating stable, cleavable linkers in antibody-drug conjugates (ADCs) and targeted drug delivery systems. It is essential for R&D scientists and process chemists in the pharmaceutical, biotechnology, and life sciences industries who require reliable, well-characterized intermediates for developing next-generation therapeutics.

Application

• ADC Linker Synthesis: A key intermediate for constructing protease-cleavable or pH-sensitive linkers in Antibody-Drug Conjugates.
• Prodrug Development: Used to create t-butyl-protected carboxylic acid prodrugs that can be activated under specific physiological conditions.
• PEGylation Reagent: Functionalizes peptides, proteins, or small molecules with a hydrophilic PEG spacer to improve solubility, stability, and pharmacokinetic profiles.
• Polymer Chemistry: Acts as a monomer or chain extender in the synthesis of specialized biodegradable or stimuli-responsive polymers.
• Bioconjugation & Crosslinking: Provides a protected handle for site-specific conjugation strategies in diagnostic assay and biosensor development.
• Chemical Biology Tools: Used to synthesize probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	Methoxycarbonyl-Peg4-T-Butyl Ester
CAS No.	2100306-74-7
Molecular Formula	C19H36O9
Molecular Weight	408.49 g/mol
Synonyms	1,11-Bis(tert-butoxy)-3,6,9-trioxa-12-oxotridecan-13-oic acid methyl ester; Methyl 1,11-bis(tert-butoxy)-3,6,9-trioxa-12-oxotridecan-13-oate; t-Butyl-PEG4-COOMe; Methoxycarbonyl-PEG4-t-butyl ester; 4,7,10,13-Tetraoxahexadecanedioic acid, 1,16-di-tert-butyl ester, 16-methyl ester; PEG4-diacid t-butyl methyl ester; Boc-PEG4-COOMe (common abbreviation); Acid-PEG4-t-butyl ester, methyl ester
EINECS	Contact for details

Quality Control

Our Methoxycarbonyl-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.