Description

T-Boc-Aminooxy-Peg1-Azide is a heterobifunctional crosslinker featuring a tert-butyloxycarbonyl (T-Boc) protected aminooxy group and a terminal azide. This compound is a critical reagent for bioorthogonal conjugation chemistry, enabling the site-specific modification of biomolecules under mild, physiological conditions. It is primarily utilized by researchers and process developers in the pharmaceutical and biotechnology industries for applications in drug discovery, bioconjugation, and the development of antibody-drug conjugates (ADCs).

Application

• Bioconjugation and ADC Development: Used for the site-specific attachment of payloads (e.g., toxins, fluorophores, drugs) to antibodies, proteins, or peptides via oxime ligation and click chemistry.
• Chemical Biology and Proteomics: Serves as a versatile tool for labeling and functionalizing biomolecules to study protein interactions, localization, and function.
• Polymer and Material Science: Acts as a functional monomer or crosslinking agent for synthesizing smart polymers, hydrogels, and functionalized surfaces with bioactive properties.
• Diagnostic Reagent Synthesis: Employed in the creation of labeled probes and assay components for diagnostic kits and imaging agents.
• Peptide and Protein Modification: Facilitates the introduction of azide handles onto peptides or proteins for subsequent click chemistry reactions, enabling modular assembly.
• Ligand-Directed Targeting: Enables the construction of targeted delivery systems by conjugating targeting ligands to various carriers or nanoparticles.

Basic Information

Product Name	T-Boc-Aminooxy-Peg1-Azide
CAS No.	2100306-67-8
Molecular Formula	C11H21N5O4
Molecular Weight	287.32 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid, 14-[(1,1-dimethylethoxy)amino]-14-oxo-; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]acetic acid N-(tert-butoxy)amide; Boc-Aminooxy-PEG1-Azide; tert-Butyl N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]carbonyloxy]carbamate; Aminooxy-PEG1-azide, Boc-protected; T-Boc-NH-O-PEG1-N3; Azido-PEG1-aminooxy, Boc protected
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg1-Azide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and development documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The product is moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.