Description

T-Boc-Aminooxy-Peg4-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a tert-butyloxycarbonyl (T-Boc) protected aminooxy group and a terminal azide. This compound is essential for creating stable, site-specific conjugations in bioconjugation and materials science, particularly through click chemistry reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Key reagent for the synthesis of Antibody-Drug Conjugates (ADCs) via oxime ligation and copper-free click chemistry.
• Functionalization of nanoparticles, surfaces, and hydrogels to introduce bioorthogonal handles for further modification.
• Preparation of PEGylated linkers and spacers to improve the solubility and pharmacokinetics of therapeutic molecules.
• Crosslinking agent in polymer chemistry for creating smart materials with tailored degradation profiles.
• Tool compound in chemical biology for site-specific protein labeling and immobilization.
• Intermediate in the development of diagnostic probes and imaging agents.

Basic Information

Product Name	T-Boc-Aminooxy-Peg4-Azide
CAS No.	2100306-64-5
Molecular Formula	C20H38N4O9
Molecular Weight	478.54 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadecan-15-amine, 15-[(1,1-Dimethylethoxy)carbonyl]aminooxy; 2,5,8,11-Tetraoxatetradecan-14-amine, 14-azido-N-[(1,1-dimethylethoxy)carbonyl]oxy; T-Boc-N-amido-PEG4-azide; Boc-Aminooxy-PEG4-N3; Azido-PEG4-aminooxy-t-butyl carbamate; tert-Butyl N-(14-azido-3,6,9,12-tetraoxatetradecyloxy)carbamate; Aminooxy-PEG4-azide Boc-protected
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg4-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.