Description

Azido-Peg2-T-Boc-Hydrazide is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a tert-butyloxycarbonyl (Boc)-protected hydrazide. This compound is a critical reagent for the controlled conjugation of biomolecules and materials via bioorthogonal click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced drug delivery systems.

Application

• Bioconjugation and ADC Development: Serves as a key linker for site-specific conjugation of cytotoxic drugs to antibodies or proteins via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• Peptide and Protein Modification: Enables the introduction of functional handles or labels onto peptides and proteins through its reactive hydrazide group after Boc deprotection.
• Polymer and Material Science: Used to functionalize surfaces, nanoparticles, and hydrogels to create bioactive materials for diagnostics and tissue engineering.
• Prodrug Synthesis: Facilitates the design of cleavable prodrug linkers that are responsive to specific physiological conditions, such as acidic tumor microenvironments.
• Crosslinking Agent: Acts as a versatile crosslinker for creating three-dimensional networks in biomaterial scaffolds.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and affinity labels for target identification and validation studies.

Basic Information

Product Name	Azido-Peg2-T-Boc-Hydrazide
CAS No.	2100306-56-5
Molecular Formula	C14H27N5O5
Molecular Weight	345.40 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]ethyl 2-(tert-butoxycarbonyl)hydrazine-1-carboxylate; Azido-PEG2-Boc-hydrazide; Boc-NHNH-PEG2-azide; 1-Boc-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxycarbonyl]hydrazine; Azido-PEG2-T-Boc-Hydrazide; tert-Butyl (2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}carbonyl)hydrazine-1-carboxylate; N-(tert-Butoxycarbonyl)-N'-[2-[2-(2-azidoethoxy)ethoxy]ethoxycarbonyl]hydrazine
EINECS	Contact for details

Quality Control

Our Azido-Peg2-T-Boc-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.