Description

Bis-Peg4-T-Butyl Ester is a high-purity, bifunctional PEG-based ester derivative, specifically designed as a versatile building block for advanced chemical synthesis. This compound is valued for its role in introducing hydrophilic polyethylene glycol (PEG) spacers and protected functional groups into target molecules, enhancing solubility and modifying pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for applications such as linker chemistry, prodrug development, and polymer modification.

Application

• Pharmaceutical Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers used in antibody-drug conjugates (ADCs) and targeted therapeutics.
• Prodrug Design: Used to incorporate PEGylated, acid-labile t-butyl ester groups into prodrug molecules to improve solubility and enable controlled drug release.
• Bioconjugation Reagent: Acts as a heterobifunctional crosslinker for modifying proteins, peptides, and other biomolecules with PEG chains.
• Polymer Chemistry: Functions as a monomer or chain extender in the synthesis of specialized PEG-based copolymers and hydrogels.
• Material Science: Employed in surface functionalization and the creation of hydrophilic coatings for biomedical devices.
• Chemical Biology Probes: Utilized in the development of tools and probes for studying biological processes, where a protected, PEGylated handle is required.

Basic Information

Product Name	Bis-Peg4-T-Butyl Ester
CAS No.	2100306-53-2
Molecular Formula	C26H50O11
Molecular Weight	538.68 g/mol
Synonyms	1,11-Bis(tert-butoxy)-3,6,9-trioxaundecane-1,11-dioate; PEG4-diacid-di-t-butyl ester; Di-tert-butyl PEG4 ester; α,ω-Bis(t-butoxycarbonyl)-tetraethylene glycol; Tetraethylene glycol di-tert-butyl ester; t-Butyl-PEG4-t-butyl ester; Bis(t-butoxycarbonyl PEG4); 3,6,9,12-Tetraoxatetradecanedioic acid, 1,14-di-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Bis-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.