Description

8-Azido-3,6-Dioxaoctanoic Acid Cyclohexylamine Salt is a specialized bifunctional linker compound featuring a reactive azide group and a carboxylic acid protected as a cyclohexylamine salt. This product is engineered for high-value applications where precise molecular conjugation is critical, offering a stable and soluble intermediate for advanced synthesis. It is primarily required by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for developing targeted drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label biomolecules like proteins, antibodies, and oligonucleotides.
• Pharmaceutical Intermediate: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, linking cytotoxic payloads to targeting moieties.
• Polymer Functionalization: Enables the introduction of reactive azide handles into polymer backbones (e.g., PEG derivatives) for creating smart materials and hydrogels.
• Diagnostic Probe Synthesis: Facilitates the development of imaging agents and fluorescent probes for in vitro and in vivo diagnostics.
• Surface Modification: Used to functionalize nanoparticles, chips, and other solid supports with azide groups for subsequent bio-immobilization.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker in materials science to create networks with specific properties.
• Peptide and Protein Modification: Allows for site-specific modification of peptides and proteins to alter their pharmacokinetics or add new functionalities.
• Academic and Industrial R&D: A critical tool for chemical biology research, enabling the study of biomolecular interactions and cellular processes.

Basic Information

Item	Details
Product Name	8-Azido-3,6-Dioxaoctanoic Acid Cyclohexylamine Salt
CAS No.	2098500-94-6
Molecular Formula	C14H26N4O4
Molecular Weight	314.38 g/mol
Synonyms	8-Azido-3,6-dioxaoctanoic acid cyclohexylamine salt; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]acetic acid cyclohexylamine salt; Azido-PEG3-acid CHA salt; CHA salt of Azido-PEG3-COOH; N3-PEG3-acid cyclohexylamine salt; Cyclohexylammonium 8-azido-3,6-dioxaoctanoate; Azido-PEG3-acid, amine salt; PEG3-azide acid CHA salt
EINECS	Contact for details

Quality Control

Our 8-Azido-3,6-Dioxaoctanoic Acid Cyclohexylamine Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and structural integrity suitable for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, supporting your R&D and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.