Description

1,1-Difluoro-6-Azaspiro[2.6]Nonane Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound matters for its critical role in modern drug discovery, particularly in the development of novel bioactive molecules where its scaffold can impart improved metabolic stability and binding affinity. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, especially for projects targeting central nervous system (CNS) disorders, enzyme inhibition, and the synthesis of complex heterocyclic libraries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Protease Inhibitor Development: The spirocyclic amine motif is valuable for creating inhibitors targeting various proteases.
• CNS Drug Discovery: Serves as a precursor for compounds designed to cross the blood-brain barrier for neurological applications.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Agrochemical Synthesis: Potential intermediate in the development of advanced herbicides or pesticides with fluorinated components.

Basic Information

Product Name	1,1-Difluoro-6-Azaspiro[2.6]Nonane Hydrochloride
CAS No.	2098002-16-3
Molecular Formula	C8H14ClF2N
Molecular Weight	197.65 g/mol
Synonyms	1,1-Difluoro-6-azaspiro[2.6]nonane HCl; 6-Azaspiro[2.6]nonane, 1,1-difluoro-, hydrochloride; 1,1-Difluoro-6-azaspiro[2.6]nonane hydrochloride; 1,1-Difluoro-6-azaspiro[2.6]nonane monohydrochloride; 2098002-16-3; 1,1-Difluoro-6-azaspiro[2.6]nonane HCl salt; Difluorinated Spirocyclic Amine Hydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-6-Azaspiro[2.6]Nonane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.