Description

tert-Butyl (2-(4-(((3-Fluoropyridin-2-Yl)Methyl)Carbamoyl)Oxazol-2-Yl)Ethyl)Carbamate is a sophisticated organic building block featuring a carbamate-protected amine linked to a fluorinated heterocyclic core. This compound is of significant value in pharmaceutical research and development, particularly for its role as a key intermediate in the synthesis of novel active pharmaceutical ingredients (APIs). Its precise molecular architecture makes it essential for medicinal chemists working in drug discovery, especially for targets requiring fluorinated pyridine and oxazole motifs. This high-purity intermediate is critical for streamlining complex synthetic routes and ensuring the reproducibility of final drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes due to its fluoropyridine and oxazole functionalities.
• Proteolysis-Targeting Chimera (PROTAC) Development: Employed in the construction of linker-warhead systems for targeted protein degradation therapies.
• Kinase Inhibitor Synthesis: A key precursor in the manufacturing of small-molecule kinase inhibitors, where the fluorinated heterocycle enhances binding affinity and metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and cellular pathways.

Basic Information

Product Name	tert-Butyl (2-(4-(((3-Fluoropyridin-2-Yl)Methyl)Carbamoyl)Oxazol-2-Yl)Ethyl)Carbamate
CAS No.	2095671-83-1
Molecular Formula	C18H23FN4O4
Molecular Weight	378.40 g/mol
Synonyms	Boc-2-(4-(((3-Fluoropyridin-2-yl)methyl)carbamoyl)oxazol-2-yl)ethylamine; 2-[[(3-Fluoropyridin-2-yl)methyl]carbamoyl]-4-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-1,3-oxazole; tert-Butyl N-[2-[4-[[(3-fluoropyridin-2-yl)methyl]carbamoyl]-1,3-oxazol-2-yl]ethyl]carbamate; 2095671-83-1; (2-(4-(((3-Fluoropyridin-2-yl)methyl)carbamoyl)oxazol-2-yl)ethyl)carbamic acid tert-butyl ester; Boc-AEEA-(3-Fluoropyridyl)oxazole carboxamide
EINECS	Contact for details

Quality Control

Our tert-Butyl (2-(4-(((3-Fluoropyridin-2-Yl)Methyl)Carbamoyl)Oxazol-2-Yl)Ethyl)Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical applications, ensuring traceability and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.