Description

5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)Uridine is a chemically modified nucleoside analog designed for advanced bioconjugation and oligonucleotide synthesis. This compound is critical for researchers and developers in the pharmaceutical and biotechnology sectors who require precise, click-chemistry compatible building blocks. Its primary value lies in enabling the site-specific functionalization of nucleic acids, which is essential for creating targeted therapeutics, diagnostic probes, and research tools. Key industries that utilize this high-purity intermediate include oligonucleotide API manufacturers, diagnostic kit developers, and academic research institutions focused on nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: Serves as a key modified phosphoramidite monomer for the solid-phase synthesis of azide-functionalized oligonucleotides.
• Bioconjugation & Click Chemistry: The 5'-azido group enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling nucleic acids with fluorophores, peptides, or other molecules.
• Antisense & siRNA Therapeutics: Used in the development of next-generation therapeutic oligonucleotides with enhanced stability and targeted delivery capabilities.
• Diagnostic Probe Development: Facilitates the creation of highly specific detection probes for PCR, FISH, and other molecular diagnostic assays.
• Chemical Biology Research: A vital tool for studying nucleic acid-protein interactions, cellular trafficking, and metabolic pathways through bioorthogonal labeling.
• Material Science: Used in the fabrication of nucleic acid-based nanomaterials and biosensors.

Basic Information

Product Name	5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)Uridine
CAS No.	2095417-60-8
Molecular Formula	C13H17N5O7
Molecular Weight	355.31 g/mol
Synonyms	5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine; 2'-O-(2-Methoxyethyl)-5'-azido-5'-deoxyuridine; 5'-N3-5'-d-2'-MOE-U; Azido-MOE-Uridine; 5'-Azido-2'-MOE-Uridine; 5'-Deoxy-5'-azido-2'-O-(2-methoxyethyl)uridine; Uridine, 5'-azido-5'-deoxy-2'-O-(2-methoxyethyl)-
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)Uridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for critical research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.