Description

3'-Azido-3'-Deoxy-5-Fluoro-β-L-Uridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is a key synthetic intermediate for the creation of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in nucleoside chemistry and prodrug development. The material is supplied with a high level of purity and batch-to-batch consistency to support critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting RNA viruses, including potential treatments for hepatitis C and other viral infections.
• Oncology Research: Serves as a precursor for fluorinated nucleoside therapeutics designed to inhibit cancer cell proliferation.
• Biochemical Probe Development: Utilized in studies to understand nucleoside metabolism and polymerase inhibition mechanisms.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry & Scale-Up: Supplied for pilot plant and commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-Azido-3'-Deoxy-5-Fluoro-β-L-Uridine
CAS No.	2095417-40-4
Molecular Formula	C9H10FN5O5
Molecular Weight	287.21 g/mol
Synonyms	3'-Azido-3'-deoxy-5-fluoro-L-uridine; 5-Fluoro-3'-azido-3'-deoxy-L-uridine; 3'-N3-5-F-L-Urd; 1-((2S,3S,4R,5R)-3-Azido-5-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; β-L-3'-Azido-3'-deoxy-5-fluorouridine; 5-Fluoro-3'-azido-2',3'-dideoxy-L-uridine (common reference); AZT-FLU L-nucleoside analog
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5-Fluoro-β-L-Uridine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical research. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, related substances, and residual solvents. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.