Description

n-(Azido-Peg2)-n-Boc-Peg4-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring an azide group and a tert-butyl ester-protected carboxylic acid, separated by distinct PEG spacer arms. This compound is specifically engineered for applications in bioconjugation and materials science, where its orthogonal reactive groups enable precise, sequential coupling strategies under mild conditions. It is a critical building block for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and advanced polymer synthesis.

Application

• Bioconjugation & Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching biomolecules (e.g., peptides, antibodies, oligonucleotides) to surfaces, nanoparticles, or other polymers via copper-free click chemistry (azide-alkyne cycloaddition) and subsequent deprotection/activation of the carboxylic acid.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of PEGylated linkers to connect cytotoxic payloads to monoclonal antibodies, improving solubility, stability, and pharmacokinetic profiles.
• PEGylation Reagent: Facilitates the site-specific PEGylation of therapeutic proteins and peptides to enhance circulatory half-life and reduce immunogenicity.
• Functional Material Synthesis: A key monomer for creating functionalized hydrogels, smart polymers, and surface coatings with tailored biological activity and responsive properties.
• Diagnostic Probe Construction: Employed in building diagnostic imaging probes (e.g., for PET, fluorescence) by conjugating targeting ligands to reporter molecules.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a soluble PEG-based scaffold or as a building block to introduce PEG chains and reactive handles into synthetic peptides.

Basic Information

Product Name	n-(Azido-Peg2)-n-Boc-Peg4-T-Butyl Ester
CAS No.	2093153-83-2
Molecular Formula	C31H58N4O13
Molecular Weight	670.81 g/mol
Synonyms	1-tert-Butyl 14-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl) 2,5,8,11-tetraoxatetradecanedioate; Azido-PEG2-Boc-PEG4-t-butyl ester; N3-PEG2-Boc-PEG4-COOtBu; Boc-PEG4-Azide t-Butyl Ester; Heterobifunctional PEG Azide t-Butyl Ester; 14-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl) 1-tert-butyl 2,5,8,11-tetraoxatetradecanedioate; Azido-PEG2-amine-Boc-PEG4-acid t-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg2)-n-Boc-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Assay	≥ 90% (by NMR)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.