Description

n-(Azido-Peg2)-n-Boc-Peg4-Acid CAS NO 2093153-82-1 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group for copper-free click chemistry and a carboxylic acid group protected by a Boc (tert-butoxycarbonyl) moiety. This compound is essential for creating stable, site-specific conjugations in aqueous environments, crucial for advanced bioconjugation strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and functionalized nanoparticles.

Application

• Bioconjugation Reagent: For the site-specific modification of proteins, antibodies, and peptides via strain-promoted azide-alkyne cycloaddition (SPAAC).
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component to attach cytotoxic payloads to monoclonal antibodies, enhancing therapeutic targeting and solubility.
• PEGylation Platform: Used to introduce hydrophilic PEG spacers onto drug molecules or surfaces to improve pharmacokinetics, solubility, and reduce immunogenicity.
• Polymer Chemistry: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels and functionalized polymers for drug delivery systems.
• Surface Functionalization: Enables the creation of biofunctional coatings on nanoparticles, biosensors, and diagnostic assay platforms.
• Protecting Group Strategy: The acid-labile Boc protecting group allows for orthogonal deprotection and sequential conjugation in multi-step synthetic routes.

Basic Information

Item	Details
Product Name	n-(Azido-Peg2)-n-Boc-Peg4-Acid
CAS No.	2093153-82-1
Molecular Formula	C24H44N4O11
Molecular Weight	564.63 g/mol
Synonyms	Azido-PEG2-Boc-PEG4-acid; 2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid, 1,1-dimethylethyl ester; Boc-N-amido-PEG4-azide; Boc-NH-PEG4-Azide; tert-Butyl 2,5,8,11,14,17,20-heptaoxa-23-azatetracosan-24-oate 23-azide; Heterobifunctional PEG linker, Azido-PEG4-Boc-acid; N-(Azido-PEG2)-N-Boc-PEG4-acid
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg2)-n-Boc-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, to ensure compliance with research and cGMP-grade standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.