Description

n-(Azido-Peg2)-n-Boc-Peg3-T-Butyl Ester is a specialized heterobifunctional polyethylene glycol (PEG) derivative, designed as a versatile linker for bioconjugation and materials science applications. This compound is critical for researchers and manufacturers requiring precise, controlled coupling of biomolecules or surfaces via its distinct azide and protected amine functional groups. It is primarily utilized in the development of advanced drug delivery systems, diagnostic reagents, and functionalized biomaterials within the pharmaceutical and biotechnology sectors.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or antibodies to other molecules, nanoparticles, or solid surfaces via click chemistry (azide-alkyne cycloaddition).
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in constructing cleavable or non-cleavable linkers for connecting cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Employed to introduce PEG chains onto therapeutic molecules to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Surface Functionalization: Used to modify the surface of nanoparticles, quantum dots, or diagnostic chips with reactive groups for subsequent biomolecule immobilization.
• Polymer and Dendrimer Synthesis: Acts as a building block for creating complex, branched, or multi-functional polymeric architectures.
• Cross-linking Agent: Facilitates the formation of hydrogels or cross-linked protein networks for tissue engineering and 3D cell culture applications.
• Proteomics Research: Utilized in chemical proteomics for labeling and enriching specific proteins or protein complexes from biological samples.
• Diagnostic Assay Development: Incorporated into the design of fluorescent, enzymatic, or other detection probes for immunoassays and biosensors.

Basic Information

Product Name	n-(Azido-Peg2)-n-Boc-Peg3-T-Butyl Ester
CAS No.	2093153-07-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-tert-Butyl 14-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl) (3S,12S)-4,11-dioxo-3,6,9,12-tetraaza-5,10-dioxapentadecan-1,15-dioate; Boc-N-amido-PEG3-azide T-butyl ester; Azido-PEG2-Boc-PEG3-T-butyl ester; N-(Azido-PEG2)-N-Boc-PEG3-acid T-butyl ester; Heterobifunctional PEG linker azide-Boc; t-Butyl 2,5,8,11-tetraoxa-14-azapentadecan-15-oate, 14-[(1,1-dimethylethoxy)carbonyl]-14-azido-; Boc-NH-PEG3-Azide t-Butyl Ester
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg2)-n-Boc-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.