Description

Methyl 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylate is a high-value, synthetically versatile bicyclic building block of significant interest in modern organic and medicinal chemistry. Its unique [1.1.1]propellane-derived, highly strained structure makes it a critical intermediate for constructing complex, three-dimensional molecular scaffolds that are difficult to access via other routes. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for applications in fragment-based drug discovery, bioisostere development, and the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for creating bioisosteres and sp3-rich fragments to improve drug-like properties.
• Agrochemical Research: Used in developing new crop protection agents and herbicides, where its rigid bicyclic core can impart unique biological activity and metabolic stability.
• Advanced Material Synthesis: Acts as a building block for specialty polymers, ligands, and functional materials that require rigid, three-dimensional architectures.
• Medicinal Chemistry & Drug Discovery: Employed as a versatile scaffold in fragment-based screening and lead optimization programs to explore novel chemical space.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, particularly in strain-release chemistry and cross-coupling reactions.

Basic Information

Product Name	Methyl 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylate
CAS No.	2092825-26-6
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	Methyl 3-hydroxybicyclo[1.1.1]pentane-1-carboxylate; 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid methyl ester; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-hydroxy-, methyl ester; Methyl 3-hydroxy-BCP-carboxylate; 3-Hydroxy-BCP-methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC, NMR, and MS, to verify identity and purity. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.