Description

5-Cbz-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is a high-value, synthetically versatile spirocyclic building block used in advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to explore novel three-dimensional chemical space and modulate the physicochemical properties of drug candidates. It is primarily utilized by R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of new chemical entities, particularly in programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry Research: Used to introduce constrained spirocyclic and aza-heterocyclic motifs into lead compounds to improve potency, selectivity, and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a specialized linker or component in the design of bifunctional molecules for targeted protein degradation.
• Peptidomimetic Synthesis: Employed to create conformationally restricted peptide analogs for enhanced bioavailability and receptor binding.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse compound libraries for drug discovery campaigns.

Basic Information

Product Name	5-Cbz-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid
CAS No.	2089652-09-3
Molecular Formula	C15H17NO4
Molecular Weight	275.30 g/mol
Synonyms	5-[(Benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-7-carboxylic acid; 5-Carbobenzyloxy-5-azaspiro[2.4]heptane-7-carboxylic Acid; 5-Azaspiro[2.4]heptane-7-carboxylic acid, 5-[(phenylmethoxy)carbonyl]-; 5-Cbz-5-aza-spiro[2.4]heptane-7-carboxylic acid; 5-[(Benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-7-carboxylic acid; 5-Cbz-5-azaspiro[2.4]heptane-7-carboxylic acid; 5-Carboxy-5-azaspiro[2.4]heptane-7-carboxylic acid benzyl ester; 5-Cbz-5-aza-spiro[2.4]heptane-7-CO2H
EINECS	Contact for details

Quality Control

Our 5-Cbz-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with ISO 9001 standards and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.