Description

tert-Butyl 5,5-Dioxo-4-Oxa-5λ6-Thia-6-Azaspiro[2.4]heptane-6-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic sulfonamide structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads due to its spirocyclic and sulfonamide motifs.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Process Chemistry: Employed in route scouting and scale-up studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Sulfonamide-Based Library Synthesis: A versatile scaffold for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 5,5-Dioxo-4-Oxa-5λ6-Thia-6-Azaspiro[2.4]heptane-6-carboxylate
CAS No.	2089649-97-6
Molecular Formula	C10H15NO5S
Molecular Weight	261.30 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-4-oxa-6-azaspiro[2.4]heptane-5,5-dione; tert-Butyl 5,5-dioxo-4-oxa-5λ6-thia-6-azaspiro[2.4]heptane-6-carboxylate; Spiro[cyclopropane-1,2'-[1,2]oxathiazolidine] 2,2-dioxide, 6-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 5,5-dioxido-4-oxa-5λ6-thia-6-azaspiro[2.4]heptane-6-carboxylate; BOC-protected spirocyclic sulfamoylating agent; CAS 2089649-97-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,5-Dioxo-4-Oxa-5λ6-Thia-6-Azaspiro[2.4]heptane-6-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.