Description

Ethyl 6-Azaspiro[3.4]Octane-8-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel drug candidates. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the spirocyclic core.
• Protease Inhibitor Development: Serves as a precursor in the creation of molecules designed to inhibit specific enzymes like proteases.
• Ligand Synthesis for Receptor Studies: Employed in the preparation of ligands for pharmacological characterization of G-protein-coupled receptors (GPCRs) or other biological targets.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions.

Basic Information

Product Name	Ethyl 6-Azaspiro[3.4]Octane-8-Carboxylate Hydrochloride
CAS No.	2089648-68-8
Molecular Formula	C10H18ClNO2
Molecular Weight	219.71 g/mol
Synonyms	Ethyl 6-Azaspiro[3.4]octane-8-carboxylate hydrochloride; 8-Carbethoxy-6-azaspiro[3.4]octane hydrochloride; 6-Azaspiro[3.4]octane-8-carboxylic acid, ethyl ester, hydrochloride; Ethyl 8-azaspiro[4.3]octane-6-carboxylate hydrochloride (possible numbering variant); Azaspirooctane ethyl carboxylate HCl; CAS 2089648-68-8
EINECS	Contact for details

Quality Control

Our Ethyl 6-Azaspiro[3.4]Octane-8-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.