Description

Propargyl-Peg3-Methyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a methyl ester. This compound is a critical building block in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require reliable, high-quality linkers for creating targeted drug conjugates, diagnostic probes, and functional hydrogels.

Application

• Bioconjugation and Click Chemistry: Serves as a key linker for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to attach payloads like drugs, dyes, or peptides to antibodies, proteins, or nanoparticles.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of linker-payload constructs for creating next-generation targeted cancer therapies.
• Proteomics and Biomarker Research: Facilitates the labeling and enrichment of proteins or glycans for mass spectrometry analysis and activity-based protein profiling.
• Polymer and Material Functionalization: Acts as a functional monomer or cross-linker to introduce alkyne handles into hydrogels, coatings, and other polymeric materials for subsequent modification.
• Diagnostic Reagent Synthesis: Employed in the production of fluorescent probes, imaging agents, and biosensor components.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a soluble PEG-based scaffold or as part of a cleavable linker system.

Basic Information

Product Name	Propargyl-Peg3-Methyl Ester
CAS No.	2086689-09-8
Molecular Formula	C13H22O6
Molecular Weight	274.31 g/mol
Synonyms	Propargyl-PEG3-methyl ester; 3,6,9-Trioxa-12-dodecynoic acid, methyl ester; Methyl 3,6,9-trioxa-12-dodecynoate; Propargyl-PEG3-COOMe; Propargyl tetraethylene glycol methyl ester; Methyl-PEG3-propargyl ester; Alkyne-PEG3-methyl ester; 12-Propynyl-3,6,9-trioxadodecanoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg3-Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.