Description

Azido-PEG3-Methyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a methyl ester terminus. This compound is a crucial building block in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for applications such as drug delivery system development, protein and peptide labeling, and the creation of functional hydrogels.

Application

• Bioconjugation and Click Chemistry: Acts as a versatile linker for coupling biomolecules (e.g., proteins, peptides, oligonucleotides) to other entities via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• Drug Delivery System Development: Used to functionalize nanoparticles, liposomes, and polymer-drug conjugates to enhance targeting, solubility, and pharmacokinetic profiles.
• Protein and Antibody Modification: Enables site-specific PEGylation (PEG modification) to improve therapeutic protein stability, reduce immunogenicity, and prolong circulation half-life.
• Materials Science and Surface Engineering: Facilitates the creation of functionalized surfaces, hydrogels, and biomaterials with tailored biological activity and properties.
• Diagnostic Probe Synthesis: Employed in the construction of fluorescent, radioactive, or other reporter-tagged probes for imaging and diagnostic assays.
• Crosslinking Agent: Serves as a crosslinker in polymer chemistry to introduce biodegradable or cleavable PEG spacers into network structures.

Basic Information

Product Name	Azido-PEG3-Methyl Ester
CAS No.	2086689-07-6
Molecular Formula	C11H21N3O5
Molecular Weight	275.30 g/mol
Synonyms	Azido-PEG3-ME; 3-Azidopropyl-PEG2-methyl ester; Methyl 3,6,9-trioxa-12-azadodecanoate; 11-Azido-3,6,9-trioxaundecanoic acid methyl ester; Azido-tri(ethylene glycol) methyl ester; N3-PEG3-Methyl Ester; PEG3-Azide Methyl Ester; Azido-PEG3-COOMe
EINECS	Contact for details

Quality Control

Our Azido-PEG3-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.