Description

2-(Azido-Peg3-Amido)-1,3-Bis(Carboxylethoxy)Propane is a heterobifunctional polyethylene glycol (PEG) derivative, featuring a reactive azide group and two carboxylic acid termini, designed for advanced bioconjugation and cross-linking applications. This compound is engineered to provide a flexible, hydrophilic spacer arm, enabling efficient and site-specific coupling between biomolecules and surfaces or other functional groups under mild, aqueous conditions. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science, particularly for creating stable, well-defined conjugates for drug delivery systems, diagnostic assays, and functional biomaterials.

Application

• Bioconjugation and Cross-linking: Site-specific coupling of proteins, peptides, antibodies, or oligonucleotides via click chemistry (azide-alkyne cycloaddition) and carbodiimide-mediated amide bond formation.
• Drug Delivery System (DDS) Development: Functionalization of nanoparticles, liposomes, or polymer carriers to create targeted and stealth therapeutic conjugates.
• Diagnostic Assay Reagent: Immobilization of capture biomolecules onto sensor surfaces, microplates, or beads for ELISA, lateral flow assays, and biosensors.
• Proteomics and Biomaterial Engineering: Modification of hydrogels, scaffolds, or surfaces to introduce bioactivity and control cell-material interactions.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Serving as a component in the design of cleavable or non-cleavable linkers for payload attachment.
• Polymer and Dendrimer Functionalization: Introducing reactive handles into polymer backbones or dendritic structures for further modular synthesis.

Basic Information

Product Name	2-(Azido-Peg3-Amido)-1,3-Bis(Carboxylethoxy)Propane
CAS No.	2086689-05-4
Molecular Formula	C19H34N4O11
Molecular Weight	494.5 g/mol
Synonyms	Azido-PEG3-acid-COOH2; 2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]acetamido]-1,3-bis(2-carboxyethoxy)propane; 1,3-Bis(2-carboxyethoxy)-2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetamido]propane; N-(Azido-PEG3)-1,3-bis(carboxyethyl)propane-1,3-diamine; Heterobifunctional PEG Azide Diacid; Azido-PEG3-tris(acetic acid); Azido-PEG3-tris(carboxymethyl)amine
EINECS	Contact for details

Quality Control

Our 2-(Azido-Peg3-Amido)-1,3-Bis(Carboxylethoxy)Propane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for functional group verification, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); desiccate upon opening and seal tightly under an inert atmosphere such as argon or nitrogen for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Azide Content (Titration)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.