Description

n-(Azido-Peg2)-n-Boc-Peg3-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal azide group and a carboxylic acid, protected by a Boc (tert-butoxycarbonyl) group on the amine. This compound is a critical building block for bioconjugation and click chemistry applications, enabling the precise, site-specific modification of biomolecules, surfaces, and polymers. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require controlled, high-yield coupling reactions.

Application

• Bioconjugation and Linker Chemistry: Used to attach drugs, dyes, or other functional molecules to antibodies, proteins, peptides, or nanoparticles via the azide-alkyne cycloaddition (click chemistry) and subsequent amide bond formation.
• PEGylation Reagent: Serves as a heterobifunctional PEG spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic biologics while introducing a clickable handle for further functionalization.
• Surface Functionalization: Employed to modify surfaces (e.g., gold, silica, polymers) with azide groups for the subsequent immobilization of biomolecules or creation of bioactive coatings.
• Polymer Synthesis: Acts as a monomer or macromonomer in the synthesis of functionalized, biocompatible block copolymers and hydrogels for drug delivery and tissue engineering.
• Proteomics Research: Utilized in activity-based protein profiling (ABPP) and chemical proteomics to label and enrich specific proteins or enzyme families.
• Diagnostic Reagent Development: Incorporated into the design of immunoassay components, biosensors, and imaging probes requiring controlled orientation and linkage.

Basic Information

Product Name	n-(Azido-Peg2)-n-Boc-Peg3-Acid
CAS No.	2086689-01-0
Molecular Formula	C24H46N4O11
Molecular Weight	566.65 g/mol
Synonyms	2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; 1-Boc-1,2-diamino-3,6,9,12,15-pentaoxaoctadecan-18-oic acid, 18-Azido-3,6,9,12,15-pentaoxaoctadecan-1-oic acid tert-butyl ester; Azido-PEG2-Boc-PEG3-acid; Boc-N-amido-PEG3-azide-PEG2-acid; Heterobifunctional PEG Azide Acid Boc-protected; 2086689-01-0
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg2)-n-Boc-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant for long-term stability. The product is light-sensitive and should be handled under inert atmosphere when possible to minimize degradation. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.