Description

n-(Azido-Peg3)-n-Bis(Peg1-T-Butyl Ester) is a heterobifunctional polyethylene glycol (PEG) derivative featuring an azide group and two carboxylic acid t-butyl ester termini. This compound matters as a versatile, high-purity linker for click chemistry and bioconjugation, enabling the precise construction of complex molecular architectures. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, functionalized PEG spacers.

Application

• As a key reagent in click chemistry for bioconjugation, utilizing the azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• For the synthesis of PEGylated drug conjugates and antibody-drug conjugates (ADCs), where the t-butyl ester groups can be deprotected to provide carboxylic acid handles for amide bond formation.
• In the development of hydrogel networks and biomaterials, where its dual functionality allows for cross-linking and modification.
• As a building block for creating diagnostic probes and imaging agents by attaching targeting molecules and fluorophores.
• For surface functionalization of nanoparticles and other substrates to impart biocompatibility and specific chemical reactivity.
• In proteomics research for the site-specific labeling of proteins and peptides.

Basic Information

Product Name	n-(Azido-Peg3)-n-Bis(Peg1-T-Butyl Ester)
CAS No.	2086689-00-9
Molecular Formula	C22H41N3O8
Molecular Weight	475.58 g/mol
Synonyms	Azido-PEG3-acid-(t-Bu ester)2; 1-Azido-3,6,9-trioxaundecane-11,11-dioic acid bis(1,1-dimethylethyl) ester; 2,2-Dimethylpropyl 11-azido-3,6,9-trioxaundecane-1,11-dioate; N3-PEG3-bis(t-butyl ester); Azido-PEG3-bis(t-butyl ester); Heterobifunctional PEG Azide t-Butyl Ester; 11-Azido-3,6,9-trioxaundecanedioic acid di-tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-Bis(Peg1-T-Butyl Ester) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Under these conditions, the product is stable for extended periods. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.