Description

Acid-Peg2-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a carboxylic acid group and a tert-butyl ester-protected terminal. This compound is engineered to serve as a versatile building block in advanced organic synthesis and bioconjugation, offering controlled reactivity and solubility enhancement. It is particularly valuable for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for constructing complex molecules, such as prodrugs, polymer-drug conjugates, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of prodrugs and active pharmaceutical ingredients (APIs) requiring PEGylation for improved pharmacokinetics.
• Bioconjugation Linker: Used to create stable linkages between biomolecules (e.g., peptides, antibodies) and payloads like drugs, dyes, or polymers, leveraging the acid group for amide bond formation.
• Polymer Chemistry: Serves as a monomer or chain extender in the synthesis of functionalized, biodegradable, or stimuli-responsive polymers for drug delivery systems.
• Material Science: Imparts hydrophilicity and functionality to surfaces and materials in the development of coatings, hydrogels, and biocompatible scaffolds.
• Chemical Biology Probes: Utilized in the design and synthesis of probes and tools for studying biological processes and target engagement.
• Diagnostic Agent Synthesis: A precursor in the manufacturing of contrast agents and other diagnostic compounds where solubility and targeting are critical.

Basic Information

Product Name	Acid-Peg2-T-Butyl Ester
CAS No.	2086688-99-3
Molecular Formula	C13H26O6
Molecular Weight	278.34 g/mol
Synonyms	2-[2-(2-tert-Butoxy-2-oxoethoxy)ethoxy]acetic acid; 3,6,9-Trioxaundecanedioic acid 11-tert-butyl ester; PEG2-acid t-butyl ester; t-Butyl-PEG2-acid; Carboxy-PEG2-t-butyl ester; α-Carboxy-ω-(tert-butoxycarbonyl)triethylene glycol; Acid-PEG2-t-Butyl Ester
EINECS	Contact for details

Quality Control

Our Acid-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.