Description

1H-Indazole-1-Acetic Acid, 3-Acetyl-5-Bromo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex indazole core structure. This compound is critical for research and development in medicinal chemistry, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to enhance drug efficacy and selectivity.
• API Synthesis: Incorporated into complex multi-step synthesis routes for the production of potential Active Pharmaceutical Ingredients (APIs).
• Oncology Drug Discovery: The bromo and acetyl functional groups make it a valuable scaffold for developing kinase inhibitors and other anticancer agents.
• Biochemical Tool Compound: Utilized in biochemical assays and as a probe to study specific enzyme interactions and biological mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Item	Detail
Product Name	1H-Indazole-1-Acetic Acid, 3-Acetyl-5-Bromo-, 1,1-Dimethylethyl Ester
CAS No.	2086183-72-2
Molecular Formula	C15H17BrN2O3
Molecular Weight	353.21 g/mol
Synonyms	tert-Butyl 3-acetyl-5-bromo-1H-indazole-1-acetate; 3-Acetyl-5-bromo-1H-indazole-1-acetic acid 1,1-dimethylethyl ester; 5-Bromo-3-acetyl-1H-indazole-1-acetic acid tert-butyl ester; tert-Butyl (3-acetyl-5-bromo-1H-indazol-1-yl)acetate; 2086183-72-2; 3-Acetyl-5-bromoindazole-1-acetic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indazole-1-Acetic Acid, 3-Acetyl-5-Bromo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. For advanced applications, synthesis can be tailored to meet specific research-grade or cGMP standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.