Description

2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-iodo-, 1,1-dimethylethyl ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and iodinated structure. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, complex drug candidates. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs) with spirocyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component in the linker or warhead design of bifunctional degraders.
• CNS Drug Discovery: The spiro[3.3]heptane scaffold is valued for its potential to improve blood-brain barrier penetration and metabolic stability in neurological targets.
• Chemical Biology Probes: The iodine atom provides a handle for further functionalization via cross-coupling reactions, useful in creating labeled probes.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization from milligram to kilogram scale for clinical trial material synthesis.

Basic Information

Product Name	2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-iodo-, 1,1-dimethylethyl ester
CAS No.	2059140-61-1
Molecular Formula	C11H18INO2
Molecular Weight	323.17 g/mol
Synonyms	tert-Butyl 6-iodo-2-azaspiro[3.3]heptane-2-carboxylate; 6-Iodo-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-iodo-, 1,1-dimethylethyl ester; 2-N-Boc-6-iodo-2-azaspiro[3.3]heptane; Boc-6-I-2-azaspiro[3.3]heptane; 2059140-61-1; tert-Butyl 6-iodo-2-azaspiro[3.3]heptane-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with custom purity grades and regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to maximize long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Assay (by HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.