Description

Methyl 3-(Bromomethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a high-value, multi-functional organic building block that combines a reactive benzyl bromide moiety with a protected boronic ester. This compound matters for its critical role in modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. Pharmaceutical, agrochemical, and advanced materials researchers need it for the efficient synthesis of complex, functionalized biaryl and heterobiaryl structures central to drug discovery and specialty chemical development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, where controlled conjugation is essential.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of bifunctional molecules for targeted protein degradation research.
• Ligand & Catalyst Development: Serves as a versatile starting material for synthesizing novel ligands and organometallic catalysts.
• Academic & Contract Research: Essential reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	Methyl 3-(Bromomethyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzoate
CAS No.	2058056-24-7
Molecular Formula	C15H20BBrO4
Molecular Weight	355.04 g/mol
Synonyms	Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(bromomethyl)benzoate; 3-(Bromomethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(bromomethyl)benzoic acid methyl ester; Pinacol ester of 3-(Bromomethyl)-2-boronobenzoic acid methyl ester; Methyl 3-(bromomethyl)-2-(pinacolatoboron)benzoate; CAS 2058056-24-7
EINECS	Contact for details

Quality Control

Our Methyl 3-(Bromomethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.