Description

1-(Phenylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core and a versatile boronic ester pinacol group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in pharmaceutical R&D and agrochemical synthesis who require reliable, high-quality precursors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex heterocyclic architectures for oncology, antiviral, and CNS therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester functionality enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides, critical for constructing drug-like molecules.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and library synthesis for exploring new chemical space and structure-activity relationships (SAR).
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Potential use in the development of organic electronic materials, such as OLEDs or conductive polymers, due to its conjugated system.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the drug discovery and development pipeline.

Basic Information

Product Name	1-(Phenylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	2058052-40-5
Molecular Formula	C23H25BN2O4S
Molecular Weight	436.33 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-Benzenesulfonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 5-Pinacolatoboryl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; Boronic acid, B-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure to air is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.