Description

1-Piperidinecarboxylic Acid, 4-[4-Fluoro-3-(Methoxycarbonyl)Phenyl]-3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3S,4R)- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant commercial importance for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought after by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in the synthesis of complex, target-specific drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders or other specialized therapeutic areas.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs) under GMP or non-GMP conditions.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries for biological screening.
• API Synthesis: Integral to the final stages of synthesizing stereochemically pure active pharmaceutical ingredients where the (3S,4R) configuration is essential for biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chemical and chiral purity.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-[4-Fluoro-3-(Methoxycarbonyl)Phenyl]-3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3S,4R)-
CAS No.	2055991-12-1
Molecular Formula	C19H26FNO5
Molecular Weight	367.41 g/mol
Synonyms	(3S,4R)-tert-Butyl 4-(4-fluoro-3-(methoxycarbonyl)phenyl)-3-(hydroxymethyl)piperidine-1-carboxylate; (3S,4R)-1-Boc-4-(4-fluoro-3-(methoxycarbonyl)phenyl)-3-(hydroxymethyl)piperidine; tert-Butyl (3S,4R)-4-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-(hydroxymethyl)piperidine-1-carboxylate; (3S,4R)-Boc-Piperidine Derivative; 1-(tert-Butoxycarbonyl)-4-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-(hydroxymethyl)piperidine, (3S,4R)- isomer; (3S,4R)-1-N-Boc-3-(hydroxymethyl)-4-[4-fluoro-3-(methoxycarbonyl)phenyl]piperidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to rigorous quality standards to ensure batch-to-batch consistency and reliability for critical R&D and scale-up work. Quality is verified through comprehensive analytical methods including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development under quality agreements and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity over time.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.