Description

6-Azaspiro[3.4]Octane-6,8-Dicarboxylic Acid, 6-(1,1-Dimethylethyl) 8-Ethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and metabolic disorders. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of innovative active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those with spirocyclic architectures for enhanced binding affinity and metabolic stability.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, high-purity heterocyclic compounds.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel methodology development.

Basic Information

Product Name	6-Azaspiro[3.4]Octane-6,8-Dicarboxylic Acid, 6-(1,1-Dimethylethyl) 8-Ethyl Ester
CAS No.	2055841-96-6
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	6-tert-Butyl 8-ethyl 6-azaspiro[3.4]octane-6,8-dicarboxylate; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-8-carboxylic acid ethyl ester; Ethyl 6-(tert-butoxycarbonyl)-6-azaspiro[3.4]octane-8-carboxylate; 6-Azaspiro[3.4]octane-6,8-dicarboxylic acid, 6-tert-butyl 8-ethyl ester; 6-Boc-6-azaspiro[3.4]octane-8-ethyl carboxylate; 6-Azaspiro[3.4]octane-6,8-dicarboxylic acid 6-tert-butyl ester 8-ethyl ester; 6-tert-Butyl 8-ethyl 6-azaspiro[3.4]octane-6,8-dicarboxylate; tert-Butyl ethyl 6-azaspiro[3.4]octane-6,8-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.