Description

Propargyl-Peg8-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a t-butyl ester. This compound is a critical intermediate for advanced bioconjugation and click chemistry applications, enabling the precise attachment of biomolecules, polymers, and other functional units. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality building blocks for drug delivery systems, diagnostic probes, and polymer synthesis.

Application

• Bioconjugation Linker: Serves as a versatile spacer and linker for attaching drugs, peptides, or fluorescent dyes to antibodies, proteins, or nanoparticles via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Polymer & Dendrimer Synthesis: Acts as a functional monomer or terminating agent for creating PEG-based block copolymers, hydrogels, and dendritic structures with tailored properties.
• Drug Delivery System Development: Used to synthesize prodrugs and to functionalize liposomes or micelles, enhancing solubility, stability, and targeted delivery of active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Formulation: Employed in the development of contrast agents, biosensors, and in-vivo imaging probes due to its biocompatibility and functional handle for labeling.
• Surface Modification: Facilitates the creation of non-fouling, functionalized surfaces on medical devices, chips, and sensors to improve biocompatibility and enable specific biomolecular capture.
• Chemical Biology Tool: A key reagent for activity-based protein profiling (ABPP) and other proteomics studies to label and study enzyme activity in complex biological systems.

Basic Information

Product Name	Propargyl-Peg8-T-Butyl Ester
CAS No.	2055014-96-3
Molecular Formula	C31H58O12
Molecular Weight	622.79 g/mol
Synonyms	Propargyl-PEG8-t-butyl ester; 2,5,8,11,14,17,20,23-Octaoxapentacos-24-yn-1-oic acid, 25-(1,1-dimethylethyl) ester; t-Butyl-PEG8-propargyl; Propargyl-PEG8-O-t-butyl; Propargyl-PEG8-t-butyl ester; 1-Propargyl-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid t-butyl ester; Propargyl-PEG8-acid t-butyl ester; Propargyl-PEG8-COOtBu
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical-grade intermediates. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing specific results for purity, moisture content, and functional group verification are available upon request. We adhere to strict in-process controls to guarantee batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.