Description

tert-Butyl 2-(3-(4-(3-Hydroxypropoxy)butoxy)propoxy)acetate is a specialized polyether ester building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a protected carboxylic acid and a terminal hydroxyl group connected by a flexible polyether spacer, makes it a versatile intermediate for constructing complex molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and specialty chemical sectors who require high-purity, functionalized intermediates for drug discovery, polymer modification, and the development of novel surfactants or ligands.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring polyethylene glycol (PEG)-like linkers or solubilizing chains.
• Polymer Chemistry: Used as a monomer or chain extender in the production of specialized polyesters, polyethers, and block copolymers with tailored hydrophilicity and biodegradability.
• Prodrug Development: The tert-butyl ester group acts as a protecting group for carboxylic acids, making this compound useful in prodrug strategies to enhance drug bioavailability and stability.
• Surface-Active Agents: Functions as a precursor for non-ionic surfactants and emulsifiers used in agrochemicals, coatings, and personal care formulations.
• Chemical Biology & Bioconjugation: The orthogonal reactive groups (protected acid and hydroxyl) enable its use in linking biomolecules, creating diagnostic probes, or modifying peptides.
• Material Science: Employed in the synthesis of advanced materials such as hydrogels, dendrimers, and non-viral gene delivery vectors due to its biocompatible polyether segment.

Basic Information

Product Name	tert-Butyl 2-(3-(4-(3-Hydroxypropoxy)butoxy)propoxy)acetate
CAS No.	2052306-04-2
Molecular Formula	C18H36O7
Molecular Weight	364.48 g/mol
Synonyms	2-[3-[4-(3-Hydroxypropoxy)butoxy]propoxy]acetic acid tert-butyl ester; tert-Butyl 2-[3-[4-(3-hydroxypropoxy)butoxy]propoxy]acetate; Acetic acid, 2-[3-[4-(3-hydroxypropoxy)butoxy]propoxy]-, 1,1-dimethylethyl ester; Poly(oxy-1,4-butanediyl), α-[2-[(1,1-dimethylethoxy)carbonyl]methoxy]-ω-hydroxy-; PEG-butanol derivative tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-(3-(4-(3-Hydroxypropoxy)butoxy)propoxy)acetate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure compliance with stringent purity and identity specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.