Description

(R)-Methyl 2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enantiomerically pure compounds. This material is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in stereoselective chemical reactions to construct molecules with defined three-dimensional structures.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs.
• Process Development & Scale-up: Serves as a starting material for optimizing synthetic routes from laboratory to pilot and commercial scale.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control.
• Peptidomimetics & Bioactive Molecule Synthesis: The amino ester structure makes it suitable for constructing peptide analogs and other biologically active compounds.

Basic Information

Product Name	(R)-Methyl 2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoate Hydrochloride
CAS No.	2049127-84-4
Molecular Formula	C11H15NO4S • HCl
Molecular Weight	293.77 g/mol (Free base: 257.30 g/mol)
Synonyms	(R)-Methyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride; D-3-(3-Methylsulfonylphenyl)alanine methyl ester hydrochloride; (R)-Methyl 3-(3-(methylsulfonyl)phenyl)-2-aminopropanoate HCl; (R)-2-Amino-3-(3-(methylsulfonyl)phenyl)propionic acid methyl ester hydrochloride; (R)-Methyl 2-amino-3-(3-methanesulfonylphenyl)propionate hydrochloride; CAS 2049127-84-4; Enantiomerically pure methyl phenylalanine derivative hydrochloride.
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-Amino-3-(3-(Methylsulfonyl)Phenyl)Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.